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EDITORIAL
Year : 2022  |  Volume : 17  |  Issue : 4  |  Page : 815

Dengue vaccination versus no vaccination: Utility analysis based on situation from a tropical endemic area


1 Private Academic Consultant Center, Bangkok, Thailand
2 Department of Community Medicine, Dr. DY Patil University, Pune, Maharashtra, India

Date of Submission18-Mar-2021
Date of Decision23-Jun-2022
Date of Acceptance24-Jun-2022
Date of Web Publication10-Feb-2023

Correspondence Address:
Dr. Rujittika Mungmunpuntipantip
Private Academic Consultant Center, Bangkok
Thailand
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/jdmimsu.jdmimsu_118_21

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How to cite this article:
Mungmunpuntipantip R, Wiwanitkit V. Dengue vaccination versus no vaccination: Utility analysis based on situation from a tropical endemic area. J Datta Meghe Inst Med Sci Univ 2022;17:815

How to cite this URL:
Mungmunpuntipantip R, Wiwanitkit V. Dengue vaccination versus no vaccination: Utility analysis based on situation from a tropical endemic area. J Datta Meghe Inst Med Sci Univ [serial online] 2022 [cited 2023 Nov 29];17:815. Available from: https://journals.lww.com/dmms/pages/default.aspx/text.asp?2022/17/4/815/369472



Dengue is an important tropical mosquito-borne disease. Dengue is common in many tropical areas, including Southeast Asia. The disease can cause an acute febrile illness with hemorrhagic complications.[1] The dengue vaccine is a new vaccine for prevention of dengue. However, the cost-effectiveness of dengue vaccine is considered low and it might not be useful for disease prevention.[2] A similar observation is also observed in another Southeast Asian report from Indonesia.[3] Adjustment of the costs is necessary for cost effectiveness in many tropical countries.[4],[5]

Regardless of the cost, an interesting question is the clinical utility of dengue vaccination. Here, the authors use local available data from a tropical country in Indochina, where dengue is endemic for utility analysis of dengue vaccination (local data are available at https://www.pidst.or.th/A655.html). The utility is defined as the overall advantage of vaccination and calculated by “disease preventive rate for hospitalization due to vaccination – disease occurrence rate of post vaccination severe dengue.” The study compared four different options: (a) no vaccination with prior dengue, (b) no vaccination without prior dengue, (c) dengue vaccination for cases with prior dengue, and (d) dengue vaccination for cases without prior dengue. The result is shown in [Table 1].
Table 1: Overall advantage of dengue vaccination in different alternatives

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According to the analysis, it is clear that the vaccination will be useful only if it is given to a case with previous dengue. Furthermore, the overall benefit of dengue vaccination in cases where no previous dengue option exists is less than the benefit of no dengue vaccination in cases where no previous dengue option exists. Hence, pre-vaccination screening for previous dengue might be considered for implementation of dengue vaccination.



 
  References Top

1.
Wiwanitkit V. Dengue fever: Diagnosis and treatment. Expert Rev Anti Infect Ther 2010;8:841-5.  Back to cited text no. 1
    
2.
Joob B, Wiwanitkit V. Cost and effectiveness of dengue vaccine: A report from endemic area, Thailand. J Med Soc 2018;32:163.  Back to cited text no. 2
  [Full text]  
3.
Suwantika AA, Supadmi W, Ali M, Abdulah R. Cost-effectiveness and budget impact analyses of dengue vaccination in Indonesia. PLoS Negl Trop Dis 2021;15:e0009664.  Back to cited text no. 3
    
4.
Shim E. Dengue dynamics and vaccine cost-effectiveness analysis in the Philippines. Am J Trop Med Hyg 2016;95:1137-47.  Back to cited text no. 4
    
5.
España G, Leidner AJ, Waterman SH, Perkins TA. Cost-effectiveness of dengue vaccination in Puerto Rico. PLoS Negl Trop Dis 2021;15:e0009606.  Back to cited text no. 5
    



 
 
    Tables

  [Table 1]



 

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