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 Table of Contents  
LETTER TO EDITOR
Year : 2022  |  Volume : 17  |  Issue : 3  |  Page : 808

Expected incidence of thrombocytopenia in influenza patient after ruling out for dengue concurrence


1 Sanitation 1 Medical Academic Center, Bangkok, Thailand
2 Department of Biological Science, Joseph Ayo Babalola University, Ikeji-Arakeji, Osun State, Nigeria

Date of Submission10-Jun-2019
Date of Decision20-Nov-2019
Date of Acceptance27-Jan-2020
Date of Web Publication2-Nov-2022

Correspondence Address:
Dr. Beuy Joob
Sanitation 1 Medical Academic Center, Bangkok
Thailand
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/jdmimsu.jdmimsu_92_19

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How to cite this article:
Joob B, Wiwanitkit V. Expected incidence of thrombocytopenia in influenza patient after ruling out for dengue concurrence. J Datta Meghe Inst Med Sci Univ 2022;17:808

How to cite this URL:
Joob B, Wiwanitkit V. Expected incidence of thrombocytopenia in influenza patient after ruling out for dengue concurrence. J Datta Meghe Inst Med Sci Univ [serial online] 2022 [cited 2023 Feb 4];17:808. Available from: http://www.journaldmims.com/text.asp?2022/17/3/808/360238



Sir,

Influenza is an important respiratory tract infection. This viral infection is still the global public health consideration. A nonrespiratory manifestation of influenza is interesting. The hematological findings in influenza include thrombocytopenia.[1] In fact, thrombocytopenia in influenza is reported for relationship with poor clinical course.[2] Nevertheless, there is still no clear explanation for pathophysiology for thrombocytopenia in influenza. In tropical country, there is a chance that influenza can co-occur with other tropical infections. The concurrence between dengue and influenza is possible. In that case, the thrombocytopenia due to dengue might be seen in the patient with co-infection.

Here, the authors use the mathematical model to estimate an expected incidence of thrombocytopenia in an influenza patient that is already ruled out for dengue concurrence. The model is developed based on the previous reports on the incidence of thrombocytopenia in influenza[3],[4] and the incidence of concurrence between influenza and dengue.[1] The data from Thailand, a tropical country in Indochina, are primarily used for modeling. Based on the available data, the observed incidence of thrombocytopenia in influenza is equal to 10.4% and 53.0%[3],[4] and the observed incidence of concurrence between influenza and dengue is equal to 1.08% (3 from 278 influenza patients).[1] Based on these data, the expected incidence for thrombocytopenia in influenza patient that is already ruled out for dengue concurrence is between 9.32% and 51.92%. The expected rate is considerable high.

Further study on the exact pathophysiology of influenza-induced thrombocytopenia is required.

Financial support and sponsorship

Nil.

Conflicts of interest

There are no conflicts of interest.



 
  References Top

1.
Chaiwarith R, Prommee N, Liwsrisakun C, Oberdorfer P, Nuntachit N, Pothirat C. A novel influenza A H1N1 clinical manifestations in patients at Chiang Mai University Hospital. J Med Assoc Thai 2011;94:908-15.  Back to cited text no. 1
    
2.
Lopez-Delgado JC, Rovira A, Esteve F, Rico N, Mañez Mendiluce R, Ballús Noguera J, et al. Thrombocytopenia as a mortality risk factor in acute respiratory failure in H1N1 influenza. Swiss Med Wkly 2013;143:w13788.  Back to cited text no. 2
    
3.
Punpanich W, Chirapanyanon P, Srisarang S. Clinical characteristics and hospital charges among Thai children hospitalized with influenza. Southeast Asian J Trop Med Public Health 2014;45:75-84.  Back to cited text no. 3
    
4.
Udompornwattana S, Srajai K, Suwan P, Tangsathapornpong A, Wittawatmongkol O, Phongsamart W, et al. The clinical features, risk of prolonged hospitalization and household infections of hospitalized children for pandemic 2009 influenza A (H1N1) virus infection in Thailand. J Med Assoc Thai 2012;95:403-11.  Back to cited text no. 4
    




 

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