| ORIGINAL ARTICLE |
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| Year : 2022 | Volume
: 17
| Issue : 1 | Page : 78-83 |
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Comparison between biomarkers high-sensitivity C-Reactive protein and N-Terminal probrain natriuretic peptide in patients with myocardial infarction
Dharmveer Sharma1, Vivek Kumar Jain1, Vidyanand Pandit2, Manish Kumar Verma3
1 Department of Biochemistry, Government Medical College, Shivpuri, Madhya Pradesh, India
2 Department of Pathology, Government Medical College, Shivpuri, Madhya Pradesh, India
3 Department of Biochemistry, GSVM Medical College, Kanpur, Uttar Pradesh, India
Correspondence Address:
Dr. Vidyanand Pandit
Department of Pathology, Government Medical College, Shivpuri, Madhya Pradesh
India
 Source of Support: None, Conflict of Interest: None  | Check |
DOI: 10.4103/jdmimsu.jdmimsu_382_21
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Background: Elevated inflammatory markers have been associated with an increased risk of future cardiovascular events, acute myocardial infarction (MI), and illness in patients with stable or unstable coronary artery disease. Aim: The present study was comparison between high-sensitivity C-reactive protein (hsCRP), NTproBNP, TnT, and creatine kinase MB (CK-MB) in patient groups and control group. Materials and Methods: The diagnostic test blood glucose and lipid profile biochemical parameter were assessed using endpoint method. hsCRP kits for human were assessed using turbidimetric immunoassay method. Serum N-terminal probrain natriuretic peptide (NT-proBNP) levels were measured by automated immunoassay. Both cardiac TnT and CK-MB mass were measured with highly specific monoclonal antibodies in a sensitive chemiluminescence assay. Results: Comparing marker levels of the two groups, Mann–Whitney U test and independent sample t-test were used. The mean NT-proBNP (pg/ml) and hsCRP (mg/L) were found significantly different and almost 24- and 8-fold higher in cases as compared to controls (610.69 ± 25.28 vs. 25.28 ± 11.76, and 4.47 ± 1.62 vs 0.52 ± 0.23; all P < 0.01). Further, the CK-MB (IU/L) and TnT (pg/ml) (mean ± standard deviation) were also high in the case group than control (166.83 ± 27.8 vs. 98.03 ± 3.05; P < 0.01 and 135.44 ± 8.79 vs 96.46 ± 2.91; P < 0.01). Conclusion: Elevated level of NT-proBNP is a strong independent prognostic predictor in patients with myocardial infarction and positive correlation between NTproBNP with TnT and CK-MB with TnT and consumption of alcohol, smoking, and tobacco may be also a risk factor for myocardial infarction.
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