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REVIEW ARTICLE
Year : 2022  |  Volume : 17  |  Issue : 1  |  Page : 170-174

Cancer-associated fibroblasts and FAP-Alpha: Its applications in odontogenic tissues


1 Department of Oral and Maxillofacial Pathology and Microbiology, D. Y. Patil University, School of Dentistry, Nerul, Navi Mumbai, Maharashtra, India
2 Department of Oral and Maxillofacial Pathology and Microbiology, Dr. D. Y. Patil University School of Dentistry, Navi Mumbai, Maharashtra, India

Correspondence Address:
Dr. Sandhya Tamgadge
Department of Oral and Maxillofacial Pathology and Microbiology, Dr. D. Y. Patil Dental College and Hospital, Sector 7, Nerul, Navi Mumbai - 400 706, Maharashtra
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/jdmimsu.jdmimsu_467_21

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Cancer has always been a mystery for researchers, health-care providers and even patients. The entire journey of a cell from physiological to pathological form has been incompletely explored. Everyday new research articles have been updated on various platforms where researchers have been making an attempt to find out the various causes of carcinogenesis. Cancer-associated fibroblasts and its one of the prime proteins FAP (FIBROBLAST ACTIVATION PROTEIN ALPHA) alpha found in the normal-appearing tumor microenvironments have been investigated by many researchers and showed a positive correlation with advanced tumor grade. It has been found highly expressive in oral squamous cell carcinoma. Odontogenic lesions too are highly destructive and show recurrence. There is a need to evaluate FAP-alpha expression in these lesions too.


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