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Year : 2021  |  Volume : 16  |  Issue : 2  |  Page : 401-403

Human leukocyte antigen and periodontal diseases


Department of Periodontics, Sharad Pawar Dental College, Datta Meghe Institute of Medical Sciences (Deemed to be University), Sawangi (M), Wardha, Maharashtra, India

Correspondence Address:
Dr. Khushboo Durge
Department of Periodontics, Sharad Pawar Dental College, Sawangi, Wardha, Maharashtra
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/jdmimsu.jdmimsu_101_20

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It is well recognized that plaque microbiota alone cannot account for periodontal tissue destruction, as some individuals are relatively at a higher risk for tissue destruction than others. Probably, some host factors have a role to play in this field. It is well documented that the human leukocyte antigens (HLA) system is a complex genetic polymorphic system in man. HLA have been considered a candidate of genetic risk markers for aggressive periodontitis (AP). The HLA play an important role in immune responsiveness and may be involved in antigen recognition of periodontal pathogens. These cell surface molecules have a key role in antigen presentation and activation of T-cells. The polymorphisms of HLA can directly affect the binding capability of antigen peptides and thus affect the antigen-specific T-cell response. Hence, these polymorphisms could represent an important susceptibility or resistance factor to periodontitis.


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