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Year : 2021  |  Volume : 16  |  Issue : 2  |  Page : 266-272

p53 Expression in Breast Carcinoma and Its Association with Tumor Aggressiveness

Department of Pathology, VSSIMSAR, Sambalpur, Odisha, India

Correspondence Address:
Dr. Alaka Sahu
Department of Pathology, VSSIMSAR, Burla, Sambalpur - 768 017, Odisha
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/jdmimsu.jdmimsu_10_21

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Background: p53 mutations are the most frequent genetic alterations in breast cancer, observed in 30% of breast carcinomas. Their distribution is highly linked to molecular subtypes. Aim: The aim of the study was to establish an association between p53expression with various tumor variables such as age, histological grade, molecular subtypes, ki67, and Nottingham prognostic index (NPI). Materials and Methods: This was a cross-sectional analysis in VSSIMSAR, Burla, Odisha, India, from November 2015 to October 2017. Immunohistochemical study was done using DAKO primary antibody for estrogen receptors, progesterone receptors, human epidermal growth factor receptor (HER2/neu), Ki-67, and p53. Results: A total number of 62 cases were studied. p53 was positive in 10 (55.6%) cases of T2 tumors, 15 (60%) cases of T3 tumors, and 13 (76.5%) cases of T4 tumors. Among 26 basal-like tumors, 16 (61.5%) were p53 positive. In 12 HER2 enriched tumors, 10 (83.3%) were p53 positive, and in 8 luminal B tumors, only 2 (25%) cases came out to be p53 positive. p53 expression has a very significant association with lymph node metastasis (P < 0.01). p53 positivity increases with higher histological grades, and its reactivity is significantly associated with Ki-67 expression (P < 0.05) and NPI (P < 0.01). Conclusion: p53 association is mostly associated with more adverse phenotype and worse overall survival. There is an increased interest in p53 based therapy.

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