• Users Online: 80
  • Home
  • Print this page
  • Email this page
Home About us Editorial board Ahead of print Current issue Search Archives Submit article Instructions Subscribe Contacts Login 


 
 Table of Contents  
LETTER TO EDITOR
Year : 2020  |  Volume : 15  |  Issue : 3  |  Page : 517

Human immunodeficiency virus-associated neuroinflammation and CD16+ pathobiological process in concurrent human immunodeficiency virus infection and parkinson disease


1 Medical Academic Center, Bangkok, Thailand
2 Dr. DY Patil University, Pune, Maharashtra, India

Date of Submission18-Nov-2019
Date of Decision15-Aug-2020
Date of Acceptance30-Aug-2020
Date of Web Publication1-Feb-2021

Correspondence Address:
Dr. Beuy Joob
Medical Academic Center, Bangkok
Thailand
Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.4103/jdmimsu.jdmimsu_183_19

Rights and Permissions

How to cite this article:
Joob B, Wiwantikit V. Human immunodeficiency virus-associated neuroinflammation and CD16+ pathobiological process in concurrent human immunodeficiency virus infection and parkinson disease. J Datta Meghe Inst Med Sci Univ 2020;15:517

How to cite this URL:
Joob B, Wiwantikit V. Human immunodeficiency virus-associated neuroinflammation and CD16+ pathobiological process in concurrent human immunodeficiency virus infection and parkinson disease. J Datta Meghe Inst Med Sci Univ [serial online] 2020 [cited 2021 Feb 25];15:517. Available from: http://www.journaldmims.com/text.asp?2020/15/3/517/308554



Sir,

The human immunodeficiency virus (HIV)-associated neuroinflammation is an important problem for HIV-infected patients. In a recent report by Moulignier et al.,[1] it was found that HIV infection in patients with underlying Parkinson disease could induce functional adaptation of dopaminergic neuron and resulted in reduced neuronal loss.[1] In fact, the interrelationship between HIV-associated neuroinflammation and Parkinson disease is interesting but not well clarified. Here, the authors tried to perform bioinformatics pathway analysis, based on pathway mapping technique as used in the previous study,[2] to identify the pathway linkage between HIV-associated neuroinflammation and Parkinson disease. From the available data in the database, an important pathogenesis mechanism of HIV-associated neuroinflammation is CD16+ monocyte transmigration across the blood–brain barrier.[3] This transmigration process is directly related to dopamine.[3] Increased dopamine results in an increased transmigration process and further results in increased HIV-associated neuroinflammation. In clinical practice, the movement disorders including to  Parkinsonism More Details is detectable in HIV-infected patients.[3] In HIV-infected cases with underlying Parkinson disease, the underlying Parkinson disease-associated neurodegeneration can result in decreased dopamine level. This can further result in decreased CD16+ monocyte transmigration and decreased HIV-associated neuroinflammation. This identified biological process might explain the rarity of HIV-associated neuroinflammation among HIV-infected patients with underlying Parkinson disease.[1] This pathobiological process is similar to the observed biological process on CD16+ suppression effect of medial cannabis.[3]

Financial support and sponsorship

Nil.

Conflicts of interest

There are no conflicts of interest.



 
  References Top

1.
Moulignier A, Gueguen A, Lescure FX, Ziegler M, Girard PM, Cardon B, et al. Does HIV infection alter Parkinson disease? J Acquir Immune Defic Syndr 2015;70:129-36.  Back to cited text no. 1
    
2.
Joob B, Wiwanitkit V. Nitric oxide, liver fluke opisthorchis viverrini, thalassemia, deferiprone, and cholangiocarcinoma: A clinical interrelationship with reference to endemic area in Indochina. J Med Soc 2019;33:62-3.  Back to cited text no. 2
  [Full text]  
3.
Mattos JP, Rosso AL, Correa RB, Novis SA. Movement disorders in 28 HIV-infected patients. Arq Neuropsiquiatr 2002;60:525-30.  Back to cited text no. 3
    




 

Top
 
 
  Search
 
Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
Access Statistics
Email Alert *
Add to My List *
* Registration required (free)

 
  In this article
References

 Article Access Statistics
    Viewed34    
    Printed4    
    Emailed0    
    PDF Downloaded3    
    Comments [Add]    

Recommend this journal


[TAG2]
[TAG3]
[TAG4]