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Year : 2020  |  Volume : 15  |  Issue : 3  |  Page : 376-381

Role of sialic acid as biochemical marker in oral leukoplakia and oral squamous cell carcinoma

Department of Oral Pathology, Sharad Pawar Dental College, Datta Meghe Institute of Medical Sciences (Deemed to be University), Sawangi(M), Wardha, Maharashtra, India

Correspondence Address:
Dr. Archana Sonone
Department of Oral Pathology, Sharad Pawar Dental College, Sawangi (Meghe), Wardha, Maharashtra
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/jdmimsu.jdmimsu_162_20

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Introduction: Tumor markers are biochemical substances released by tumor cells either due to the reason or consequence of carcinogenesis process. Neoplasms often have an increased concentration of sialic acid on the tumor cell surface and are shed or secreted by some of these cells which increase the concentration in blood. Aim and Objectives: We aimed to determine the serum levels of total sialic acid (TSA), lipid-bound sialic acid (LBSA), and ratio of TSA to total protein (TP) in patients with oral leukoplakia (LP) and oral squamous cell carcinoma (OSCC) patients. Materials and Methods: The study comprises 75 participants which include 25 cases of LP, 25 cases of OSCC, and 25 cases of healthy cases as control. Ten-milliliter intravenous blood was collected under aseptic condition, and biochemical analysis of TSA, LBSA, and TP was done by spectrophotometer. Results: We observed that the levels of TSA, LBSA, and TSA/TP were significantly increased in Oral Leukoplakia (OLP) and OSCC as compared to the healthy control group. Conclusion: The increased level of TSA, LBSA, and TSA/TP in LP helps to determine the early stage of the disease. Further differentiation in grades of OSCC is also possible by these biochemical markers. Thus, serum levels of total antioxidant status, LBSA, and TSA/TP can be used as diagnostic and prognostic markers.

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