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Year : 2020  |  Volume : 15  |  Issue : 2  |  Page : 232-237

Evaluation of cytopenias in pediatric patients for etiology

1 Department of Pathology, Jawaharlal Nehru Medical College, Datta Meghe Institute of Medical Sciences (Deemed to be University), Sawangi (Meghe), Wardha, Maharashtra, India
2 Department of Medicine, Jawaharlal Nehru Medical College, Datta Meghe Institute of Medical Sciences (Deemed to be University), Sawangi (Meghe), Wardha, Maharashtra, India

Correspondence Address:
Dr. Shweta Bahadure
DMIMS, Sawangi (M), Wardha, Maharashtra
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/jdmimsu.jdmimsu_127_20

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Background: Pancytopenia is a common occurrence in paediatric patients. Aetiology of bicytopenia/ pancytopenia varies widely children, ranging from transient marrow suppression to marrow infiltration by life threatening malignancies. In time recognition of the underlying pathology will not only have an impact on mortality and morbidity but also help in treating simple and easily treatable conditions causing pancytopenia. Aim: To evaluate the etiological and clinicohaematological profile in children with cytopenias. Objectives: To study the clinical presentations in patients with pancytopenia/bicytopenia and evaluate hematological parameters and the bone marrow aspirates. Materials and Method: The present work was carried out in the hematology section of Department of Pathology, of a central Indian medical college and rural hospital from December 2017 to December 2018. 100 patients in paediatric age group having pancytopenia/bicytopenia on peripheral smear were included in the study. All relevant investigations were carried out including Bone marrow aspiration. A correlation between bicytopenia/ pancytopenia with symptoms and etiology was made. Result: The main presenting features of children with both pancytopenia and bicytopenia was fever and the commonest non-malignant conditions causing bicytopenia was megaloblastic anaemia and aplastic anaemia in pancytopenia and the commonest malignant condition which was associated with bicytopenia and pancytopenia was acute leukaemia. Conclusion: Primary haematological investigations along with bone marrow aspiration in cytopenic patients which will be helpful for understanding the disease process; diagnosis, or will help to rule out the causes of, cytopenia; and in planning further investigations and management of cytopenic patients.

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