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ORIGINAL ARTICLE
Year : 2020  |  Volume : 15  |  Issue : 2  |  Page : 202-208

Comparison of various scoring systems by immunohistochemistry for evaluating hormone receptors (Estrogen receptor and progesterone receptor) in carcinoma of breast


Department of Pathology, Jawaharlal Nehru Medical College, Datta Meghe Institute of Medical Sciences (Deemed to be University), Sawangi(Meghe), Wardha, Maharashtra, India

Correspondence Address:
Dr. Prachi Dileep Rai
Post-Graduate Student, Dept. of Pathology, Jawaharlal Nehru Medical College, DMIMS(DU), Sawangi(M), Wardha
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/jdmimsu.jdmimsu_7_20

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Background: Immunohistochemistry (IHC) is used to assess hormone receptor status evaluating hormone receptors (estrogen receptor and progesterone receptor [ER/PR]) in infiltrating ductal carcinoma of breast and determined by scoring systems: Allred (quick) and H scoring system. The present study intended to evaluate the values of these score systems in terms of correlation with Bloom-Richardson grading system of breast carcinoma. Aim: To compare Allred and H scoring systems for evaluating hormone receptors in carcinoma of breast by IHC with modified Bloom-Richardson's grading system. Objective: (1) To confirm and classify histopathology of breast tissue by routine hematoxylin and eosin staining. (2) To obtain grading by Bloom-Richardson grading system. (3) To evaluate breast carcinoma by IHC and assess by Allred and H scoring system of hormone receptors. (4) To compare these scoring systems with Bloom-Richardson grading system. Study Design: Observational, cross-sectional, and comparative. Materials and Methods: BR grade and HR status of 65 surgically resected specimens of carcinoma breast were determined by routine histopathological examination and IHC. Allred and H scoring systems were employed to evaluate HR status. Statistical Analysis: Using Chi-square test and P < 0.05 considered as level of significance. Results: The common grade was Grade II accounting to 73.85% followed by Grade I and Grade III, i.e., 16.92% and 9.23%, respectively. Immunohistochemical analysis was done and most cases belonged to ER(−)/PR(−) category, i.e., 30 cases (46.16%). Allred and H scores were analyzed and compared these scores with Bloom-Richardson Grading system. According to Pearson's correlation matrix, it was observed that a statistical significant correlation was found between Allred and H score system and had an equivalent value for ER and PR (P < 0.0001). Conclusion: The present study had shown that there was no difference between Allred and H score system and had a good correlation with BR grading system as both being semi-quantitative methods and can be practiced regularly for assessment of HR.


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