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ORIGINAL ARTICLE
Year : 2020  |  Volume : 15  |  Issue : 1  |  Page : 21-25

The association of lipid profile and uric acid levels in normotensive, preeclamptic pregnancy – A hospital-based study


Department of Biochemistry, Jawaharlal Nehru Medical College, Datta Meghe Institute of Medical Sciences (Deemed to be University), Sawangi (Meghe), Wardha, Maharashtra, India

Correspondence Address:
Dr. Archana Dhok
Department of Biochemistry, Jawaharlal Nehru Medical College and Datta Meghe Institute of Medical Science, Sawangi (Meghe), Wardha, Maharashtra
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/jdmimsu.jdmimsu_19_20

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Background: Eclampsia is a severe complication of preeclampsia (PE). This can create additional complications during pregnancy. It is a rare but serious condition where high blood pressure (BP) results in seizures during pregnancy and associated with risk for mother and fetus. The investigations of serum lipid profile serum uric acid are and BP with body mass index (BMI) highly suggested the feature of disease. Objective: The objective of the study is to find out the association between serum lipid profile and serum uric acid level in normotensive and preeclamptic pregnant women. Materials and Methods: A prospective case–control study was conducted in the Department of Biochemistry at Jawaharlal Nehru Medical College and Datta Meghe Institute of Medical Sciences, Sawangi (Meghe) Wardha, Maharashtra, India, with individuals suffering with severe PE to the obstetric unit of hospital. Serum lipid profile and uric acid levels were done by 159 patients suffer from PE and compare with 150 age-matched normotensive controls. Results: The average BMI in study group (preeclamptic pregnant women) was significantly higher than control group (P < 0.001). The BP was high in preeclamptic pregnant women than normal women. Statistically significant difference was observed in the levels of CH, triglycerides, high-density lipoprotein (HDL), and uric acid in the age group up to 25 and 26–32 years. There was no statically significantly difference observed in the age group of 33–39 years. HDL level was statically insignificant in both the groups. Conclusion: Serum lipid profile and serum uric acid are very useful markers for early detection, to identification of complications, and reduce the risk of occurrence in PE. Early detection is going to aid in better management which is important to improve the maternal and fetal complications.


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