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ORIGINAL ARTICLE
Year : 2020  |  Volume : 15  |  Issue : 1  |  Page : 16-20

Biomarkers for prediction of preterm delivery: A hospital-based study


1 Department of Biochemistry, Jawaharlal Nehru Medical College, Datta Meghe Institute of Medical Sciences, Wardha, Maharashtra, India
2 Biochemistry, Datta Meghe Medical College, SMHRC (Datta Meghe Institute of Medical Sciences, Wardha, Maharashtra, India
3 Biochemistry; Department of OBGY, Datta Meghe Medical College, SMHRC (Datta Meghe Institute of Medical Sciences, Wardha, Maharashtra, India
4 Department of OBGY, Jawaharlal Nehru Medical College, Datta Meghe Institute of Medical Sciences, Wardha, Maharashtra, India

Correspondence Address:
Dr. Ranjit Ambad
Department of Biochemistry, DMMC and SMHRC, Nagpur - 441 110, Maharashtra
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/jdmimsu.jdmimsu_33_20

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Introduction: Preterm delivery (PTD) is a significant determinant of morbidity and neonatal mortality. Preterm babies are prone to severe neonatal illness or death. PTD is one of the unresolved problems in clinical obstetrics and one of the greatest threats to the developing fetus; predictive biomarker needs to be identified for premature delivery. Therefore, the aim of this study was to assess the serum levels of hemoglobin, iron, alkaline ferritin phosphatase and ceruloplasmin in preterm and full-term delivery. Materials and Methods: The present study includes total 60 participants that comprise thirty women presenting with preterm onset of labor followed by delivery and thirty women who delivered at term served as controls. Blood samples from the patients were obtained for Iron, Ferritin, alkaline phosphatase and ceruloplasmin estimation, when patient was in labor. Results: Serum alkaline phosphatase levels were significantly increased (P ≤ 0.05) in PTD as compared to full-term delivery. Serum ceruloplasmin levels were significantly increased in PTD as compare to the full-term delivery (P ≤ 0.05). Serum ferritin levels were significantly increased (P < 0.001) in PTD as compared to full-term delivery. Serum iron levels were nonsignificantly increased in PTD as compare to the full-term delivery.(P ≤ 0.05). Conclusion: Significant rise in serum ceruloplasmin, ferritin and alkaline phosphatase in PTD as compared to full-term delivery indicate that these biomarkers can be used as predictive biomarker for PTD. Moreover, these parameters are cost effective, simple to perform and less time-consuming and indicative of subclinical infections of pregnancy which could be one of the reasons for PTD.


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