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ORIGINAL ARTICLE
Year : 2019  |  Volume : 14  |  Issue : 4  |  Page : 378-382

The assessment of expression of midkine in epithelial dysplasia and oral squamous cell carcinoma


1 Department of Oral Pathology, Malla Reddy Institute of Dental Sciences, Hyderabad, Telangana, India
2 Department of Oral Pathology and Microbiology, Sharad Pawar Dental College and Hospital, Datta Meghe Institute of Medical Sciences (Deemed to be University), Wardha, Maharashtra, India

Correspondence Address:
Dr. Alka Hande
Department of Oral Pathology and Microbiology, Sharad Pawar Dental College and Hospital, Datta Meghe Institute of Medical Sciences (Deemed to be University), Sawangi (Meghe), Wardha - 442 001, Maharashtra
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/jdmimsu.jdmimsu_178_19

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Background: Oral squamous cell carcinoma (OSCC) is categorized by a cancerous tissue growth of the epithelial cells of the oral cavity and is brought about by an array of genomic abnormalities. The survival rate of OSCC has remained nearly unchanged. For this reason, the identification of new molecules that could serve as targets for antineoplastic therapies is of prime importance. Midkine (MK) is considered to be a novel marker for determining prognosis and in early detection of cancer. Our study aims at assessing the expression of MK in oral epithelial dysplasia and OSCC. It is also an attempt to find correlation between the expression of MK and 3-year postoperative survival of patients with OSCC. Materials and Methods: The study included fifty histopathologically diagnosed cases of OSCC of various grades and fifty histopathologically diagnosed cases of epithelial dysplasia from the archives of the department of oral pathology and microbiology. These 100 samples were retrieved from a period of 3 years, i.e. 2009 to 2012. Results: Out of fifty patients with epithelial dysplasia, 47 (94%) patients showed negative expression for MK and only 3 (6%) patients showed positive expression for MK. The percentage of MK expression was PDSCC (100%), MDSCC (93%), and (76%) WDSCC showed positive expression of MK. As the Broder's grading progresses, from well to moderate to poor, the expression of MK also increased. Conclusion: According to our results, it shows that MK should be considered a target for the treatment of OSCC.


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