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Year : 2019  |  Volume : 14  |  Issue : 4  |  Page : 342-345

A comparative clinical study of the precorneal tear film in diabetic and nondiabetic persons

Department of Ophthalmology, Jawaharlal Nehru Medical College, Datta Meghe Institute of Medical sciences, Wardha, Maharashtra, India

Correspondence Address:
Dr. Yash Hada
63, Geetanjali, Rajput-Boarding, Ratlam - 457 001, Maharashtra
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/jdmimsu.jdmimsu_176_19

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Context: The study objective was to compare precorneal tear film in terms of amount and stability in diabetic and nondiabetic individuals. Aims: The aim was to study the effect of diabetes on the amount and stability of precorneal tear film. Settings and Design: This is a hospital-based, prospective, case–controlled, observational study of 1-year duration. Sixty-five sequentially collected patients with diabetes and 65 age- and sex-matched nondiabetics, attending the ophthalmology outpatient department/inpatient department at AVBRH were selected for the study after taking the inclusion and exclusion criteria into consideration. Informed consent was taken from all participants after approval by the Institutional Ethical Committee of the college. Subjects and Methods: After enrollment of the participants to the study, all underwent a thorough ophthalmic examination. Tear film break-up time (TBUT) and Schirmer's test without anesthesia followed by with anesthesia were calculated. Statistical Analysis Used: Statistical analysis was done by using descriptive and inferential statistics using Chi-square test and Student's unpaired t-test, SPSS 17.0 version and GraphPad 6.0 version software were used in the analysis, and P <0.05 was considered as level of statistical significance (P < 0.05). Results: Patients with diabetes showed more unstable tear film as compared to nondiabetics of the same age and sex. The amount of tear film measurement also decreases in diabetics. A higher number of positive test results for both Schirmer's test and TBUT test were found in patients having duration of diabetes > 5 years. Conclusions: Longer duration of diabetes is associated with dry eye. Diabetes is associated with reduction in the amount of precorneal tear film as well as an unstable precorneal tear film.

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