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Year : 2019  |  Volume : 14  |  Issue : 3  |  Page : 268-271

Role of caspases in periodontal diseases


Department of Periodontics and Implantology, Sharad Pawar Dental College, Datta Meghe Institute of Medical Sciences (Deemed to be University), Wardha, Maharashtra, India

Correspondence Address:
Dr. Sudhindra Baliga
Department of Periodontics, Sharad Pawar Dental College, Datta Meghe Institute of Medical Sciences (Deemed to be University), Sawangi (Meghe), Wardha, Maharashtra
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/jdmimsu.jdmimsu_39_19

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Periodontitis is initiated by various Gram-negative bacteria characterized by the destruction of the periodontal tissue. Intracellular proteases, caspases that are the key mediators of apoptosis, are shown to involve in disease progression. The activation of caspase-3 and caspase-7 is considerably enhanced in the gingival tissue from patients with periodontitis. A considerable number of cells in the gingival epithelium and connective tissue revealed active caspases, whereas in healthy tissue, almost no caspase activation was observed. These results therefore suggest that caspase activation may be functionally involved in periodontitis-associated tissue damage.


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