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Year : 2019  |  Volume : 14  |  Issue : 3  |  Page : 237-240

Studies on the Association of DEFB1 Gene Polymorphism (rs11362 and rs1799946) and Dental Caries in South Indian Population

1 Faculty of Allied Health Sciences, Chettinad Hospital and Research Institute (CHRI), Chettinad Academy of Research and Education (CARE), Kelambakkam, Tamil Nadu, India
2 Department of Periodontics, Chettinad Dental College and Research Institute (CDCRI), Kelambakkam, Tamil Nadu, India

Correspondence Address:
Dr. Gowtham Kumar Subbaraj
Faculty of Allied Health Sciences, Chettinad Academy of Research and Education, OMR, Kelambakkam - 603 103, Tamil Nadu
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/jdmimsu.jdmimsu_102_17

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Background: Caries development in the teeth is multifactorial diseases where the environment, and the genetic factors play an important role in the onset and recurrence. Defensins are small, cationic, cysteine-rich peptides found to be active against microorganisms including bacteria, fungi and many non-enveloped and enveloped viruses. It play a significant role in defense against numerous pathogens, and they are deliberated part of the innate immunity. They have usually been considered to contribute to mucosal health. Defensin (DEFB1) gene polymorphisms may modulate human beta defensin (HBD-1) levels might be related to pathogenesis of numerous ailments. Aim: The present investigation was aimed to understand the association of two single-nucleotide polymorphisms (rs1799946 and rs11362) of DEFB1 gene with dental caries. Results: we could found that the single-nucleotide polymorphism (SNP) rs11362 is positively associated with the progression of dental caries in the tested population. Conclusion: our analysis possibly identified the accentuate relationship between dental caries and the SNP rs11362 polymorphism of the defensin gene (DEFB1), innate immune players in the oral area.

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