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Year : 2019  |  Volume : 14  |  Issue : 3  |  Page : 162-165

Correlation of Ki-67 labeling index in cervical intraepithelial neoplasia with histomorphologic grading system

Department of Pathology, Jawaharlal Nehru Medical College, DMIMS(DU), Sawangi(M), Maharashtra, India

Correspondence Address:
Dr. Pratibha Dawande
Meghe Heights, Building No. 1, Jawaharlal Nehru Medical College, Sawangi (Meghe), Wardha, Maharashtra
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/jdmimsu.jdmimsu_44_19

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Background: Worldwide cervical cancer ranks as a major health problem for women. The cervical carcinoma is preceded by premalignant dysplastic changes in normal squamous epithelial layer which is called as cervical intraepithelial neoplasia (CIN). Aim: The aim of the study is to assess the utility of Ki-67 labeling index (LI) in grading of CIN. Objectives: The objective of the study is to identify potential corelation between histomorphological grading and Ki-67 LI of CIN. Materials and Methods: The present study was carried out as an observational type of study. The study was carried out from August 1, 2016, to July 31, 2018, in the Department of Pathology in co-ordination with the Department of Obstetrics and Gynecology, Jawaharlal Nehru Medical College, Sawangi (M), Wardha, Maharashtra. A total of 82 specimens which include cervical biopsies and hysterectomy specimen formed a part of the present study, of which 59 cases were prospective and remaining 23 cases considered were retrospective. Results: Tumor cell proliferation as measured by Ki-67 proliferative marker shows a linear correlation with histopathological grading of cervical dysplasia as per the WHO classification. With increasing grades of CIN, Ki-67 LI also increases. Conclusion: It can be stated that to determine the grades of cervical dysplasia, Ki-67 antigen should be used as an adjunct with histopathological grading which remains as the “Gold Standard.“

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