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ORIGINAL ARTICLE
Year : 2018  |  Volume : 13  |  Issue : 4  |  Page : 195-198

Association between C-reactive protein and interleukin-6 levels in subclinical hypothyroid patients


Department of Biochemistry, NKP Salve Institute of Medical Sciences and Research Centre, Nagpur, Maharashtra, India

Correspondence Address:
Dr. Madhur Gupta
Department of Biochemistry, NKP Salve Institute of Medical Sciences and Research Centre, Digdoh Hill, Hingna Road, Nagpur - 440 019, Maharashtra
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/jdmimsu.jdmimsu_6_18

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Background: The relationship between subclinical hypothyroidism (SCH) and cardiovascular disease has been one of the most popular topics recently. Our study aims to investigate the presence of the well-known preceding clinical situations of atherosclerosis such as endothelial dysfunction and inflammation in SCH. Materials and Methods: The study population comprised 50 patients with recently diagnosed SCH and 50 healthy controls. Thyroid-stimulating hormone (TSH), free triiodothyronine (FT3), and free thyroxine (FT4) were estimated by enzyme-linked fluorescent immunoassay for the diagnosis of SCH. Total cholesterol (TC), triglycerides, and high-density lipoprotein cholesterol (HDLC) were estimated by kit method in Siemens machine. Low-density lipoprotein cholesterol (LDLC) and very LDLC were calculated using Friedewald formula. Inflammatory marker C-reactive protein was estimated by kit method in Siemens and IL-6 by enzyme-linked immunosorbent assay. Results: In this study, the level of TSH ± standard deviation (8.56 ± 1.26 vs. 0.63 ± 0.16) was significantly higher (<0.001) in SCH patients, whereas FT3and FT4levels were within the normal range. TC, triglycerides, and LDLC were significantly higher in patients group, while the HDLC was significantly lower in SCH patients compared to euthyroid group. TSH level was positively correlated with inflammatory markers in SCH. Conclusion: This study suggests that SCH patients have increased inflammatory markers along with dyslipidemia due to that the future risk of further development of cardiovascular disorder can occur. Level of inflammatory makers increases in patients as disease progresses if left untreated.


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